Ebola: Experimental drug ZMapp is '100% effective' in animal trials

<div dir="ltr" style="text-align: left;" trbidi="on"> <br /> <div class="caption full-width" style="clear: both; float: none; margin: 0px 0px 15px; position: relative;"> <span style="background-color: rgba(255, 255, 255, 0);">     <img alt="Ebola virus" height="351" src="http://news.bbcimg.co.uk/media/images/77267000/jpg/_77267254_c0215902-coloured_tem_of_the_ebola_virus-spl.jpg" style="-webkit-user-select: none; border: 0px; font-style: italic; position: relative;" width="624" />A</span></div> <div class="embedded-hyper" style="clear: right; display: inline; float: right; margin: 0px -160px 0px 16px; overflow: hidden; position: relative; width: 144px;"> <a class="hidden" href="http://www.bbc.co.uk/news/health-28980153#story_continues_1" style="font-weight: bold; left: -5000px; position: absolute; text-decoration: none; top: -5000px;"><span style="color: black;"><span style="background-color: rgba(255, 255, 255, 0);">Continue reading the main story</span></span></a><div class="hyperpuff"> <h2 style="border-bottom-color: rgb(221, 221, 221); border-bottom-style: solid; border-bottom-width: 1px; border-top-color: rgb(221, 221, 221); border-top-style: solid; border-top-width: 1px; margin: 0px 0px 8px; overflow: hidden; padding: 12px 0px; position: relative; text-rendering: optimizelegibility;"> <a href="http://www.bbc.co.uk/news/world-africa-28754546" style="display: block; margin-bottom: -13px; margin-top: -13px; padding: 13px 8px; position: relative; text-decoration: none; z-index: 1;"><span style="color: black; font-size: small;"><span style="background-color: rgba(255, 255, 255, 0);">Ebola outbreak</span></span></a></h2> <ul style="list-style: none; margin: 0px 0px 16px; padding: 0px;"> <li style="background-image: none; margin: 0px 0px 8px; padding: 0px; position: relative; text-rendering: auto;"><a class="story" href="http://www.bbc.co.uk/news/world-africa-28940025" rel="published-1409096157259" style="background-color: rgba(255, 255, 255, 0); font-weight: bold; text-decoration: none;"><span style="color: black;">How to avoid Ebola</span></a></li> <li style="background-image: none; margin: 0px 0px 8px; padding: 0px; position: relative; text-rendering: auto;"><a class="story" href="http://www.bbc.co.uk/news/world-africa-28852352" rel="published-1408497066553" style="background-color: rgba(255, 255, 255, 0); font-weight: bold; text-decoration: none;"><span style="color: black;">Doctor's report</span></a></li> <li style="background-image: none; margin: 0px 0px 8px; padding: 0px; position: relative; text-rendering: auto;"><a class="story" href="http://www.bbc.co.uk/news/world-africa-26835233" rel="published-1396365946570" style="background-color: rgba(255, 255, 255, 0); font-weight: bold; text-decoration: none;"><span style="color: black;">Why so dangerous?</span></a></li> <li style="background-image: none; margin: 0px 0px 8px; padding: 0px; position: relative; text-rendering: auto;"><a class="story" href="http://www.bbc.co.uk/news/business-28865434" rel="published-1408575780579" style="background-color: rgba(255, 255, 255, 0); font-weight: bold; text-decoration: none;"><span style="color: black;">Economic 'devastation'</span></a></li> </ul> </div> </div> <div class="introduction" id="story_continues_1" style="clear: left; font-weight: bold; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">The only clinical trial data on the experimental Ebola drug ZMapp shows it is 100% effective in monkey studies, even in later stages of the infection.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">The researchers, <a href="http://dx.doi.org/10.1038/nature13777" style="font-weight: bold; text-decoration: none;">publishing their data in Nature</a>, said it was a "very important step forward".</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Yet the limited supplies will not help the 20,000 people predicted to be infected during the outbreak in West Africa.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">And two out of seven people given the drug, have later died from the disease.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">ZMapp has been dubbed the "secret serum" as it is still in the experimental stages of drug development with, until now, no public data on effectiveness.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Doctors have turned to it as there is no cure for Ebola, which has killed more than 1,500 people since it started in Guinea.</span></div> <span class="cross-head" style="display: block; font-weight: bold; margin: 0px 0px 16px; text-rendering: optimizelegibility;"><span style="background-color: rgba(255, 255, 255, 0);">Cocktail</span></span><br /> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Researchers have been investigating different combinations of antibodies, a part of the immune system which binds to viruses, as a therapy.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Previous combinations have shown some effectiveness in animal studies. ZMapp is the latest cocktail and contains three antibodies.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Trials on 18 rhesus macaques infected with Ebola showed 100% survival.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">This included animals given the drug up to five days after infection. For the monkeys this would be a relatively late stage in the infection, around three days before it becomes fatal.</span></div> <div class="caption full-width" style="clear: both; float: none; margin: 0px 0px 15px; position: relative;"> <span style="background-color: rgba(255, 255, 255, 0);"><img alt="William Pooley" height="351" src="http://news.bbcimg.co.uk/media/images/77157000/jpg/_77157526_pooley.jpg" style="-webkit-user-select: none; border: 0px; font-style: italic; position: relative;" width="624" /></span><span style="display: block; width: 624px;"><span style="background-color: rgba(255, 255, 255, 0);">William Pooley, from the UK, has been given the ZMapp drug</span></span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Scientists say this is significant as previous therapies needed to be given before symptoms even appeared.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">One of the researchers, Dr Gary Kobinger from the Public Health Agency of Canada, said this was a huge step up from previous antibody combinations.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">"The level of improvement was beyond my own expectation, I was quite surprised that the best combination would rescue animals as far as day five, it was fantastic news.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">"What was very exceptional is that we could rescue some of the animals that had advanced disease."</span></div> <span class="cross-head" style="display: block; font-weight: bold; margin: 0px 0px 16px; text-rendering: optimizelegibility;"><span style="background-color: rgba(255, 255, 255, 0);">Human implications?</span></span><br /> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">However, there is always caution when interpreting the implications for humans from animal data.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">A Liberian doctor, one of three taking the drug in the country, and a Spanish priest both died from the infection despite ZMapp treatment.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">William Pooley, the first Briton to contract Ebola during this outbreak, has been given the experimental drug ZMapp as were two US doctors who recovered.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">The course of the infection is slower in humans than macaques so it has been cautiously estimated that ZMapp may be effective as late as day nine or 11 after infection.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">But Dr Kobinger said: "We know there is a point of no return where there is too much damage to major organs, so there's a limit."</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">The group wants to start clinical trials in people to truly assess the effectiveness of the drug.</span></div> <div class="caption full-width" style="clear: both; float: none; margin: 0px 0px 15px; position: relative;"> <span style="background-color: rgba(255, 255, 255, 0);"><img alt="Ebola health workers in Liberia" height="351" src="http://news.bbcimg.co.uk/media/images/77263000/jpg/_77263861_454204690.jpg" style="-webkit-user-select: none; border: 0px; font-style: italic; position: relative;" width="624" /></span><span style="display: block; width: 624px;"><span style="background-color: rgba(255, 255, 255, 0);">The drug is unlikely to help the 20,000 people expected to be infected</span></span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Commenting on the findings, Prof Jonathan Ball, a virologist at the University of Nottingham, told the BBC: "Before, ZMapp was a total mystery.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">"This is an incredible improvement on those earlier cocktails, to have 100% clearance and most importantly that clearance when they've started to show outward signs of infection."</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Referring to the seven treated patients, he added: "Clearly there is the caveat that all evidence in humans is anecdotal and no hard evidence has been released on what happens to the virus in those patients."</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">Prof Peter Piot, the director of the London School of Hygiene and Tropical Medicine, said: "I never thought that 40 years after I encountered the first Ebola outbreak, this disease would still be taking lives on such a devastating scale.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">"This well designed trial in non-human primates provides the most convincing evidence to date that ZMapp may be an effective treatment of Ebola infection in humans.</span></div> <div style="clear: left; margin-bottom: 18px; padding: 0px; text-rendering: auto;"> <span style="background-color: rgba(255, 255, 255, 0);">"It is now critical that human trials start as soon as possible. "</span></div> <div class="caption body-width" style="clear: both; float: none; margin: 0px 0px 15px; position: relative;"> <span style="background-color: rgba(255, 255, 255, 0);"><img alt="line" height="2" src="http://news.bbcimg.co.uk/media/images/75306000/jpg/_75306515_line976.jpg" style="-webkit-user-select: none; border: 0px; font-style: italic; position: relative;" width="464" /></span></div> <span class="cross-head" style="display: block; font-weight: bold; margin: 0px 0px 16px; text-rendering: optimizelegibility;"><span style="background-color: rgba(255, 255, 255, 0);">Ebola Virus Disease (EVD)</span></span><br /> <ul style="list-style: none; margin: 0px 0px 16px; padding: 0px;"> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Symptoms include high fever, bleeding and central nervous system damage</span></li> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Spread by body fluids, such as blood and saliva</span></li> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Fatality rate can reach 90% - but current outbreak has mortality rate of about 55%</span></li> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Incubation period is two to 21 days</span></li> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">There is no vaccine or cure</span></li> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Supportive care such as rehydrating patients who have diarrhoea and vomiting can help recovery</span></li> <li style="background-image: url(http://news.bbcimg.co.uk/view/3_0_21/cream/hi/shared/img/story_sprite.gif); background-position: -1200px 5px; margin: 0px 0px 8px; padding: 0px 0px 0px 16px; text-rendering: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Fruit bats, a delicacy for some West Africans, are considered to be virus's natural host</span></li> <li style="background-color: white; color: #505050; font-family: Arial, Helmet, Freesans, sans-serif; font-size: 13px; line-height: 16px;"></li> </ul> </div>

Ebola: Experimental drug ZMapp is '100% effective' in animal trials

      A Continue reading the main story Ebola outbreak How to avoid Ebola Doctor's report Why so dangerous? Economic 'de...

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Japan ready to offer flu drug for Ebola treatment

<div dir="ltr" style="text-align: left;" trbidi="on"> <div> <div class="wp-caption aligncenter" id="attachment_633134" style="width: 630px;"> <a href="http://newsinfo.inquirer.net/files/2014/08/anti-influenza-drug.jpg" style="background-color: rgba(255, 255, 255, 0);"><span style="color: black;"><img alt="anti influenza drug" class=" wp-image-633134 " height="334" pagespeed_high_res_src="http://1-ps.googleusercontent.com/h/newsinfo.inquirer.net/files/2014/08/620x334xanti-influenza-drug.jpg.pagespeed.ic.NMgF0isgY1.jpg" src="http://1-ps.googleusercontent.com/h/newsinfo.inquirer.net/files/2014/08/620x334xanti-influenza-drug.jpg.pagespeed.ic.NMgF0isgY1.jpg" title="anti influenza drug" width="620" /></span></a><br /> <div class="wp-caption-text"> <span style="background-color: rgba(255, 255, 255, 0);">Anti-influenza tablets fabipiravir are shown in this photo. AP</span></div> <div class="wp-caption-text"> <span style="background-color: rgba(255, 255, 255, 0);"><br /></span></div> </div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">TOKYO—Japan  said Monday it is ready to provide a Japanese-developed anti-influenza drug as a possible treatment for the rapidly expanding  Ebola  outbreak.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Chief Cabinet Secretary Yoshihide Suga told reporters that  Japan  can offer favipiravir, developed by a subsidiary of Fujifilm Holdings Corp., at any time at the request of the World Health Organization.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">The drug, with the brand name Avigan, was developed by Fujifilm subsidiary Toyama Chemical Co. to treat new and re-emerging influenza viruses, and has not been proven to be effective against  Ebola.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Favipiravir was approved by  Japan’s  health ministry in March for use against influenza. Fujifilm is in talks with the U.S. Food and Drug Administration, through a U.S. partner, Medivector, to prepare for clinical testing of the drug in treating  Ebola, company spokesman Takao Aoki said.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">He said  Ebola  and influenza viruses are the same general type, and a similar response can theoretically be expected from  Ebola.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Favipiravir inhibits viral gene replication within infected cells to prevent propagation, while other anti-viral drugs often are designed to inhibit the release of new viral particles to prevent the spread of infection, the company said.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">The company has enough stock of favipiravir for more than 20,000 patients, Aoki said.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Suga, the Cabinet spokesman, said  Japan  is watching for a decision by WHO that would provide more details on the use of untested drugs against  Ebola. In case of an emergency,  Japan  may respond to individual requests before any further decision by WHO, he said.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">WHO said earlier this month that it is ethical to use untested drugs on  Ebola  patients given the magnitude of the outbreak.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Several drugs are being developed for the treatment of  Ebola. They are still in the early stages and there is no proven treatment or vaccine for the often fatal disease.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Recently, two American doctors recovered from  Ebola  after being treated with the experimental drug ZMapp, though it was unclear whether they were cured by the drug.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">However, a Liberian doctor who was among three Africans to receive ZMapp recently died, the country’s information minister said Monday.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Only six people in the world are known to have received ZMapp. The small supply is now said to be exhausted, and it is expected to be months before more can be produced by its U.S. maker, Mapp Biopharmaceutical Inc.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">ZMapp had never been tested on humans, although an early version worked in some Ebola-infected monkeys. It is aimed at boosting the immune system’s efforts to fight off  Ebola.</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Asked about the drug being offered from  Japan, Liberian Information Minister Lewis Brown said, “Although we will continue to emphasize prevention, we remain open to all available curative opportunities.”</span></div> <div> <br /> <span style="background-color: rgba(255, 255, 255, 0);">Ebola  has killed more than 1,400 people in West Africa in the latest outbreak.</span></div> </div>

Japan ready to offer flu drug for Ebola treatment

Anti-influenza tablets fabipiravir are shown in this photo. AP TOKYO—Japan  said Monday it is ready to provide a Japanese-develope...

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Doctors Without Borders say control of Ebola epidemic will take 6 months

<div dir="ltr" style="text-align: left;" trbidi="on"> <div class="post-body entry-content" id="post-body-4362384119090564936" itemprop="description articleBody" style="position: relative; width: 616px;"> <div class="separator" style="clear: both; text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh5k4RbGmi7I3bfqMrPCYw1UGAK8UuEd-7SGqEhfBIlwQ2RphDqsvedpWr5PdA_Xnmm5gpjIQfykVVb3pbolU47SPT3Qf5_Xy7jnEWm3Etm5fs_6mIuSQvTlncCZ0KP4oV0eLA-tUg47Fc/s1600/b.jpg" style="-webkit-box-shadow: rgba(0, 0, 0, 0.2) 0px 0px 0px; border-bottom-left-radius: 0px; border-bottom-right-radius: 0px; border-top-left-radius: 0px; border-top-right-radius: 0px; border: 1px solid rgb(153, 0, 0); box-shadow: rgba(0, 0, 0, 0.2) 0px 0px 0px; padding: 8px;" /><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgo9IhyHBXhstldPazaFECKrZjpthXpceTEDzTZCpovGpSVJGyblKkTD83zhBN_OwJm_Tf8-bZkQUENwiH48X0oaF-C3ePucwoV5lIUtJhH5l6np9sUXoraicOF4m6brm3MFoi65n47ZS0/s1600/a.jpg" style="-webkit-box-shadow: rgba(0, 0, 0, 0.2) 0px 0px 0px; border-bottom-left-radius: 0px; border-bottom-right-radius: 0px; border-top-left-radius: 0px; border-top-right-radius: 0px; border: 1px solid rgb(153, 0, 0); box-shadow: rgba(0, 0, 0, 0.2) 0px 0px 0px; padding: 8px;" /></span></div> <span style="background-color: rgba(255, 255, 255, 0);">The International President of Doctors Without Borders, Joanne Liu (pictured left), said today August 15th that it will take six months to bring the current Ebola epidemic sweeping through West Africa under control. She said this after a 10-day trip to some countries in West Africa where the outbreak has so far occurred. Liu, who met with Ebola patients & doctors, said the outbreak felt like 'wartime'</span><blockquote class="tr_bq"> <span style="background-color: rgba(255, 255, 255, 0);">"The main thing I come back to is that it is deteriorating faster, moving faster than we can respond to. To put it in context with my time with DWB, I really feel that it is like wartime, in terms of fear and nobody knowing what is going on. We need a response in terms of international organizations and states, and it needs to happen now if we want to contain this epidemic. Over the next six months we should get the upper hand on the epidemic, this is my gut feeling. We need people with a hands-on operational mindset to combat the outbreak." she said</span></blockquote> </div> </div>

Doctors Without Borders say control of Ebola epidemic will take 6 months

The International President of Doctors Without Borders, Joanne Liu (pictured left), said today August 15th that it will take six months ...

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Liberia to Get the Ebola Drug: Death Toll From Ebola Outbreak Tops 1,000

<div dir="ltr" style="text-align: left;" trbidi="on"> <div> <div class="last-updated" style="-webkit-text-size-adjust: 100%; background-color: white; bottom: 0px; box-sizing: border-box; color: #666666; font-family: SkyTextRegular, Helvetica, Arial, Verdana; font-size: 0.875rem; line-height: 1.125rem; margin-bottom: 40px; max-width: 40%; position: absolute; right: 0px; text-align: right;"> <div class="last-updated__text" style="box-sizing: border-box; padding: 0px;"> </div> </div> </div> <div class="last-updated" style="-webkit-text-size-adjust: 100%; background-color: white; bottom: 0px; box-sizing: border-box; color: #666666; font-family: SkyTextRegular, Helvetica, Arial, Verdana; font-size: 0.875rem; line-height: 1.125rem; margin-bottom: 40px; max-width: 40%; position: absolute; right: 0px; text-align: right;"> <div class="last-updated__text" style="box-sizing: border-box; padding: 0px;"> </div> </div> <div> <div class="story__standfirst" style="box-sizing: border-box; float: left; margin-bottom: 40px; max-width: 64%;"> <span style="background-color: rgba(255, 255, 255, 0);">Some 1,000 people are confirmed dead from the disease as the US approves a request for an experimental drug to be sent to Liberia.</span></div> <div class="last-updated" style="bottom: 0px; box-sizing: border-box; margin-bottom: 40px; max-width: 40%; position: absolute; right: 0px; text-align: right;"> <div class="last-updated__text" style="box-sizing: border-box; padding: 0px;"> </div> </div> </div> <div> <section class="story__media" style="box-sizing: border-box;"><div class="module module--primary" style="box-sizing: border-box; margin: 0px 0px 25px; width: 660px;"> <div class="module video" data-format-high="http://video.news.sky.com/video/h264/vod/700/2014/08/120814WORLDEbolaOutbreak0400WEBVT1407814394777700.mp4" data-format-low="http://video.news.sky.com/video/h264/vod/374/2014/08/120814WORLDEbolaOutbreak0400WEBVT1407814394777374.mp4" style="box-sizing: border-box; margin: 0px 0px 25px; overflow: hidden; width: 660px;"> <div class="video__placeholder-wrapper js-video" style="box-sizing: border-box; cursor: pointer; height: 0px; padding-bottom: 371px; position: relative; width: 660px;"> <div class="image" style="box-sizing: border-box;"> <div class="image__wrapper image__wrapper--16x9" style="box-sizing: border-box; overflow: hidden; padding-bottom: 371px; position: relative;"> <img alt="" class="image__item video__teaser-image js-responsive" data-breakpoint="" data-sizes="144x81 362x204 762x428 942x530" data-sizes-wide="" data-template="http://media.skynews.com/media/images/generated/2014/8/12/328801/default/v1/rtr421w1-1-{width}x{height}.jpg" src="http://media.skynews.com/media/images/generated/2014/8/12/328801/default/v1/rtr421w1-1-942x530.jpg" style="border: 1px solid rgb(220, 220, 220); box-sizing: border-box; display: block; height: 371px; max-width: 100%; page-break-inside: avoid; position: absolute; vertical-align: middle; width: 660px;" /></div> </div> <button aria-labelledby="video__caption-1317125" class="video__play--icon" style="background-image: url(http://news.sky.com/images/ffa94923.play-icon.png); background-size: contain; border: none; bottom: 8px; cursor: pointer; height: 46px; left: 7px; margin: 0px; position: absolute; width: 46px;"><span class="video__play-a11y" style="border: 0px; box-sizing: border-box; clip: rect(1px 1px 1px 1px); display: inline-block; height: 1px; overflow: hidden; padding: 0px; position: absolute !important; text-align: left; width: 1px;"><span style="font-family: Times; font-size: small;"><span style="background-color: rgba(255, 255, 255, 0);">Play video</span></span></span></button></div> <span class="video__caption" id="video__caption-1317125" style="box-sizing: border-box; display: block; min-height: 40px; padding: 10px 8px; width: 660px;"><span style="background-color: rgba(255, 255, 255, 0);"><span class="video__type" style="box-sizing: border-box;">Video:</span> <span class="video__teaser" style="box-sizing: border-box;">Ebola Outbreak Death Toll Rises</span></span></span></div> </div> </section><div class="story__content-wrapper" style="box-sizing: border-box;"> <div class="share" style="box-sizing: border-box; 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margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">The death toll from the ebola outbreak in West Africa has passed 1,000 people, according to the World Health Organisation (WHO).</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">The health agency said some 1,013 people have died from the disease which has struck in Guinea, Liberia and Sierra Leone.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">Residents in countries ravaged by the disease have been gripped by panic, with radical containment measures causing transport problems, price rises and shortages of food.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">The rising death toll came as Liberia's presidency said the US has approved a request for sample doses of an experimental drug to be sent to Liberia.</span></div> <div class="image image--inline" style="box-sizing: border-box; clear: both; margin: 0px auto 1em; max-width: 540px;"> <div class="image__wrapper image__wrapper--4x3" style="box-sizing: border-box; overflow: hidden; padding-bottom: 405px; position: relative;"> <img alt="" class="image__item js-responsive" data-breakpoint="" data-sizes="91x68 300x225 480x360" data-sizes-wide="" data-template="http://media.skynews.com/media/images/generated/2014/8/12/328800/default/v1/rtr421s9-1-{width}x{height}.jpg" src="http://media.skynews.com/media/images/generated/2014/8/12/328800/default/v1/rtr421s9-1-480x360.jpg" style="border: 1px solid rgb(220, 220, 220); box-sizing: border-box; display: block; height: 405px; max-width: 100%; page-break-inside: avoid; position: absolute; vertical-align: middle; width: 540px;" /></div> <div class="image__caption" style="box-sizing: border-box; margin-bottom: 1.25rem; min-height: 40px; padding: 10px 8px;"> <span style="background-color: rgba(255, 255, 255, 0);">Liberian soldiers check people travelling in Bomi County</span></div> </div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">The presidency announced that the ZMapp drug would be delivered to Liberia by a US government representative this week to treat doctors infected with the disease.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">However, a spokesperson for the US Health and Human Services (HHS) Department said US authorities had simply helped connect the Liberian government with the drug's manufacturer.</span></div> <div class="module module--inline video" data-format-high="http://video.news.sky.com/video/h264/vod/700/2014/07/300714EBOLAAUTHERED1700PKG1406737200487700.mp4" data-format-low="http://video.news.sky.com/video/h264/vod/374/2014/07/300714EBOLAAUTHERED1700PKG1406737200487374.mp4" style="box-sizing: border-box; clear: both; margin: 0px auto 1em; max-width: 540px; width: 540px;"> <div class="video__placeholder-wrapper js-video" style="box-sizing: border-box; cursor: pointer; height: 0px; padding-bottom: 303px; position: relative; width: 540px;"> <div class="image" style="box-sizing: border-box;"> <div class="image__wrapper image__wrapper--16x9" style="box-sizing: border-box; overflow: hidden; padding-bottom: 303px; position: relative;"> <img alt="" class="image__item video__teaser-image js-responsive" data-breakpoint="" data-sizes="144x81 362x204 762x428 942x530" data-sizes-wide="" data-template="http://media.skynews.com/media/images/generated/2012/7/29/184165/default/v3/ebola-virus-1-{width}x{height}.jpg" src="http://media.skynews.com/media/images/generated/2012/7/29/184165/default/v3/ebola-virus-1-942x530.jpg" style="border: 1px solid rgb(220, 220, 220); box-sizing: border-box; display: block; height: 303px; max-width: 100%; page-break-inside: avoid; position: absolute; vertical-align: middle; width: 540px;" /></div> </div> <button aria-labelledby="video__caption-1310346" class="video__play--icon" style="background-image: url(http://news.sky.com/images/ffa94923.play-icon.png); background-repeat: no-repeat no-repeat; background-size: contain; border: none; bottom: 8px; cursor: pointer; height: 46px; left: 7px; margin: 0px; position: absolute; width: 46px;"><span class="video__play-a11y" style="border: 0px; box-sizing: border-box; clip: rect(1px 1px 1px 1px); display: inline-block; height: 1px; overflow: hidden; padding: 0px; position: absolute !important; text-align: left; width: 1px;"><span style="font-family: Times; font-size: small;"><span style="background-color: rgba(255, 255, 255, 0);">Play video</span></span></span></button></div> <span class="video__caption" id="video__caption-1310346" style="box-sizing: border-box; display: block; min-height: 40px; padding: 10px 8px; width: 540px;"><span style="background-color: rgba(255, 255, 255, 0);"><span class="video__type" style="box-sizing: border-box;">Video:</span> <span class="video__teaser" style="box-sizing: border-box;">Deadly Ebola Virus Explained</span></span></span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">Doctors in Spain have already imported ZMapp to treat a priest evacuated from Liberia after he tested positive for ebola.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">ZMapp has been successfully tested on monkeys, but only recently used on humans. The drug is also being tested on two Americans infected with the disease.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">The latest outbreak of ebola has killed around 55-60% of those infected with the disease.</span></div> <div class="module module--inline video" data-format-high="http://video.news.sky.com/video/h264/vod/700/2014/08/070814EBOLAMOORE1700PKG1407428027716700.mp4" data-format-low="http://video.news.sky.com/video/h264/vod/374/2014/08/070814EBOLAMOORE1700PKG1407428027716374.mp4" style="box-sizing: border-box; clear: both; margin: 0px auto 1em; max-width: 540px; width: 540px;"> <div class="video__placeholder-wrapper js-video" style="box-sizing: border-box; cursor: pointer; height: 0px; padding-bottom: 303px; position: relative; width: 540px;"> <div class="image" style="box-sizing: border-box;"> <div class="image__wrapper image__wrapper--16x9" style="box-sizing: border-box; overflow: hidden; padding-bottom: 303px; position: relative;"> <img alt="" class="image__item video__teaser-image js-responsive" data-breakpoint="" data-sizes="144x81 362x204 762x428 942x530" data-sizes-wide="" data-template="http://media.skynews.com/media/images/generated/2014/8/7/327879/default/v2/453249502-1-{width}x{height}.jpg" src="http://media.skynews.com/media/images/generated/2014/8/7/327879/default/v2/453249502-1-942x530.jpg" style="border: 1px solid rgb(220, 220, 220); box-sizing: border-box; display: block; height: 303px; max-width: 100%; page-break-inside: avoid; position: absolute; vertical-align: middle; width: 540px;" /></div> </div> <button aria-labelledby="video__caption-1314876" class="video__play--icon" style="background-image: url(http://news.sky.com/images/ffa94923.play-icon.png); background-repeat: no-repeat no-repeat; background-size: contain; border: none; bottom: 8px; cursor: pointer; height: 46px; left: 7px; margin: 0px; position: absolute; width: 46px;"><span class="video__play-a11y" style="border: 0px; box-sizing: border-box; clip: rect(1px 1px 1px 1px); display: inline-block; height: 1px; overflow: hidden; padding: 0px; position: absolute !important; text-align: left; width: 1px;"><span style="font-family: Times; font-size: small;"><span style="background-color: rgba(255, 255, 255, 0);">Play video</span></span></span></button></div> <span class="video__caption" id="video__caption-1314876" style="box-sizing: border-box; display: block; min-height: 40px; padding: 10px 8px; width: 540px;"><span style="background-color: rgba(255, 255, 255, 0);"><span class="video__type" style="box-sizing: border-box;">Video:</span> <span class="video__teaser" style="box-sizing: border-box;">WHO Under Pressure Over Ebola Drug</span></span></span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">But a British hygiene expert working with Medecins Sans Frontieres (MSF) has told Sky News the statistics do not reveal the true picture of how serious the situation is.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">Cokie van der Velde, who has worked with MSF for 12 years, said: "What we need is more agencies to come forward working in these countries to reverse this epidemic.</span></div> <div style="box-sizing: border-box; margin-bottom: 1em; margin-left: auto; margin-right: auto; max-width: 540px;"> <span style="background-color: rgba(255, 255, 255, 0);">"The numbers of dead and infected don't show the real situation. There are deaths in villages and all over [Liberia] which are not being recorded."</span></div> <div class="module module--inline video" data-format-high="http://video.news.sky.com/video/h264/vod/700/2014/08/EbolaCookieVanDerVelde08001407755330999700.mp4" data-format-low="http://video.news.sky.com/video/h264/vod/374/2014/08/EbolaCookieVanDerVelde08001407755330999374.mp4" style="box-sizing: border-box; clear: both; margin: 0px auto 1em; max-width: 540px; width: 540px;"> <div class="video__placeholder-wrapper js-video" style="box-sizing: border-box; cursor: pointer; height: 0px; padding-bottom: 303px; position: relative; width: 540px;"> <div class="image" style="box-sizing: border-box;"> <div class="image__wrapper image__wrapper--16x9" style="box-sizing: border-box; overflow: hidden; padding-bottom: 303px; position: relative;"> <img alt="" class="image__item video__teaser-image js-responsive" data-breakpoint="" data-sizes="144x81 362x204 762x428 942x530" data-sizes-wide="" data-template="http://media.skynews.com/media/images/generated/2014/8/8/328176/default/v2/ebola-1-{width}x{height}.jpg" src="http://media.skynews.com/media/images/generated/2014/8/8/328176/default/v2/ebola-1-942x530.jpg" style="border: 1px solid rgb(220, 220, 220); box-sizing: border-box; display: block; height: 303px; max-width: 100%; page-break-inside: avoid; position: absolute; vertical-align: middle; width: 540px;" /></div> </div> <button aria-labelledby="video__caption-1316770" class="video__play--icon" style="background-image: url(http://news.sky.com/images/ffa94923.play-icon.png); background-repeat: no-repeat no-repeat; background-size: contain; border: none; bottom: 8px; cursor: pointer; height: 46px; left: 7px; margin: 0px; position: absolute; width: 46px;"><span class="video__play-a11y" style="border: 0px; box-sizing: border-box; clip: rect(1px 1px 1px 1px); display: inline-block; height: 1px; overflow: hidden; padding: 0px; position: absolute !important; text-align: left; width: 1px;"><span style="font-family: Times; font-size: small;"><span style="background-color: rgba(255, 255, 255, 0);">Play video</span></span></span></button></div> <span class="video__caption" id="video__caption-1316770" style="box-sizing: border-box; display: block; min-height: 40px; padding: 10px 8px; width: 540px;"><span style="background-color: rgba(255, 255, 255, 0);"><span class="video__type" style="box-sizing: border-box;">Video:</span> <span class="video__teaser" style="box-sizing: border-box;">West Africa Ebola Situation 'Dire'</span></span></span></div> </section><section class="partner-links" style="box-sizing: border-box; margin: 0px auto 60px; max-width: 540px; overflow: hidden;"><div class="partner-links__external" style="box-sizing: border-box;"> <h2 class="partner-links__title" style="border-bottom-color: rgb(220, 220, 220); border-bottom-style: solid; border-bottom-width: 1px; box-sizing: border-box; clear: left; font-weight: 400; margin: 0px 0px 20px; padding: 0px 0px 6px; position: relative; top: -3px;"> <span style="font-size: small;"><span style="background-color: rgba(255, 255, 255, 0);">From Around The Web</span></span></h2> <ul class="partner-links__list js-partner-links" style="box-sizing: border-box; margin: 0px; padding: 0px;"> <li class="partner-links__item partner-links__item--1 partner-links__item--odd" style="box-sizing: border-box; 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Liberia to Get the Ebola Drug: Death Toll From Ebola Outbreak Tops 1,000

Some 1,000 people are confirmed dead from the disease as the US approves a request for an experimental drug to be sent to Liber...

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Nine questions about new Ebola drug

<div dir="ltr" style="text-align: left;" trbidi="on"> <h1 class="entry-title posttitle" itemprop="name headline" style="border: 0px; margin: 10px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline; width: 2462px;"> <span style="background-color: rgba(255, 255, 255, 0);">Two American missionary workers infected with the deadly Ebola virus were given an experimental drug that seems to have saved their lives.</span></h1> <div id="entryContainer" style="border: 0px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"> <div class="entry entry-content" itemprop="articleBody" style="border: 0px; margin: 0px; outline: 0px; padding: 0px 6px 0px 0px; text-align: justify; vertical-align: baseline;"> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">Dr. Kent Brantly was given the medication, ZMapp, shortly after telling his doctors he thought he would die, according to a source familiar with his case. Within an hour, doctors say his symptoms — labored breathing and a widespread rash — dramatically improved. Nancy Writebol, another missionary working with Samaritan’s Purse, received two doses of the medication and has also shown significant improvement, sources say.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">As there is no proven treatment and no vaccine for Ebola, this experimental drug is raising lots of questions.</span></div> <br /> <div class="wp-caption alignleft" id="attachment_458445" style="border: 0px; float: left; font-style: inherit; margin: 0px 20px 20px 0px; outline: 0px; padding: 0px; vertical-align: baseline; width: 422px;"> <div style="text-align: left;"> <a href="http://dvsl3w2q45hb8.cloudfront.net/wp-content/uploads/2014/08/Ebola-doc.gif" style="-webkit-transition: background-color, border-top-color; background-color: rgba(255, 255, 255, 0); border: 0px; font-style: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: none; transition: background-color, border-top-color; vertical-align: baseline;"><span style="color: black;"><img alt="Health workers evacuating the remains of an Ebola Virus Disease victim." class="wp-image-458445 size-full" height="274" src="http://dvsl3w2q45hb8.cloudfront.net/wp-content/uploads/2014/08/Ebola-doc.gif" style="-webkit-transition: margin 0.2s linear, box-shadow; border: none; box-shadow: rgba(0, 0, 0, 0.247059) 1px 1px 1px; margin: 0px; padding: 0px; transition: margin 0.2s linear, box-shadow;" width="412" /></span></a></div> <div class="wp-caption-text" style="border: 0px; outline: 0px; padding: 0px 8px 0px 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">Health workers evacuating the remains of an Ebola Virus Disease victim.</span></div> </div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">1. Who makes the drug?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">The drug was developed by the biotech firm Mapp Biopharmaceutical Inc., which is based in San Diego. The company was founded in 2003 “to develop novel pharmaceuticals for the prevention and treatment of infectious diseases, focusing on unmet needs in global health and biodefense,” according to its website.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">Mapp Biopharmaceutical has been working with the National Institutes of Health and the Defense Threat Reduction Agency, an arm of the military responsible for countering weapons of mass destruction, to develop an Ebola treatment for several years.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">2. Are there other experimental Ebola drugs out there?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">Yes. In March, the NIH awarded a five-year, $28 million grant to establish a collaboration between researchers from 15 institutions who were working to fight Ebola.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">“A whole menu of antibodies have been identified as potentially therapeutic, and researchers are eager to figure out which combinations are most effective and why,” a news release about the grant said.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">Tekmira, a Vancouver-based company that has a $140 million contract with the U.S. Department of Defense to develop an Ebola drug, began Phase 1 trials with its drug in January. But the FDA recently halted the trial, asking for more information.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">At least one potential Ebola vaccine has been tested in healthy human volunteers, according to Thomas Geisbert, a leading researcher at the University of Texas Medical Branch. And last week, the NIH announced a safety trial of another Ebola vaccine will start as early as September.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">3. How does ZMapp work?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">Antibodies are proteins used by the immune system to mark and destroy foreign, or harmful, cells. A monoclonal antibody is similar, except it’s engineered in a lab so it will attach to specific parts of a dangerous cell, according to the Mayo Clinic, mimicking your immune system’s natural response. Monoclonal antibodies are used to treat many different types of conditions.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">The medicine given to Brantly and Writebol abroad was a three-mouse monoclonal antibody, meaning that mice were exposed to fragments of the Ebola virus and then the antibodies generated within the mice’s blood were harvested to create the medicine.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">However, the drug can also be produced with proteins made from tobacco plants. ZMapp manufacturer Kentucky BioProcessing in Owensboro has been working with Samaritan’s Purse and Emory University Hospital to provide limited quantities of the drug to Emory, according to company spokesman David Howard.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">4. Why did American missionary workers get the drug?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">Many have asked why these two workers received the experimental drug when so many — around 1,600 — others in West Africa also have the virus.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">The World Health Organization says it was not involved in the decision to treat Brantly and Writebol. Both patients had to give consent to receive the drug, knowing it had never been tested in humans before.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">The process by which the medication was made available to the American patients may have fallen under the U.S. Food and Drug Administration’s “compassionate use” regulation, which allows access to investigational drugs outside clinical trials.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">5. Did doctors know it would work?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">No. The drug had shown promise in primates, but even in those experiments, just eight monkeys received the treatment. In any case, the human immune system can react differently than primates’, which is why drugs are required to undergo human clinical trials before being approved by government agencies for widespread use.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">The two Americans’ cases will be studied further to determine how the drug worked with their immune systems.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">6. Will the drug be made available to other Ebola patients?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">It’s unclear. Rolling out an untested drug during a massive outbreak would be very difficult, Doctors Without Borders said in a statement. Experimental drugs typically not mass-produced, and tracking the success of such a drug if used would require extra medical staff where resources are already scarce.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, says scientists have to be careful about assuming this drug will work in other patients as it appears to have worked in Brantly.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">“Having worked with administering antibodies for people for a really long time, that would be distinctly unusual,” he told CNN. “As we all know in medicine … you have to withhold judgment.”</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">7. Does the company have more vials of the drug?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">The company has very few doses ready for patient use, Fauci told CNN.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">“(Kentucky BioProcessing) is working closely with Mapp, various government agencies, and other parties to increase production of ZMapp, but this process will take several months,” Howard said.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">8. Who paid for the drug and how much did it cost?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">We don’t know. Samaritan’s Purse covered the cost of Brantly and Writebol’s evacuations but did not pay for the drug, according to a spokesman.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">When a patient gets an experimental drug, the drug company can donate the product under compassionate use. Mapp Biopharmaceutical Inc. might have done that in this case.</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">Health insurance companies typically do not pick up the tab for treatments that have not been approved by the FDA. But they usually would cover the cost of any doctor fees associated with giving the drug and any costs associated with monitoring how the drug is working.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; vertical-align: baseline;"> </div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">9. Would this drug stop the Ebola epidemic?</span></div> <div style="text-align: left;"> <span style="background-color: rgba(255, 255, 255, 0);">If it were widely available, it certainly couldn’t hurt. An effective Ebola drug could help doctors treat the deadly virus, which is killing about 60% of the people infected in West Africa. But a vaccine would be a much more effective tool in stopping this, and future, epidemics.</span></div> <br /> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">Vaccines are given to healthy people to prevent them from ever becoming infected. One challenge with Ebola, experts say, is that companies don’t believe they could make much money from developing a vaccine, so few companies show interest.</span></div> <div style="border: 0px; margin-bottom: 15px; outline: 0px; padding: 0px; text-align: left; vertical-align: baseline;"> <span style="background-color: rgba(255, 255, 255, 0);">*Source: CNN</span></div> <div class="OUTBRAIN" data-browser="safari" data-dynload="" data-ob-mark="true" data-os="ipad" data-src="http://www.vanguardngr.com/2014/08/nine-questions-new-ebola-drug/" id="outbrain_widget_0" obdone="true" style="border: 0px; clear: both; font-style: inherit; margin: 0px; outline: 0px; padding: 5px 0px; vertical-align: baseline;"> <div class="ob_brnBox_cont NA" style="border: 0px; font-style: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"> <span class="ob_empty" style="background-color: rgba(255, 255, 255, 0); border: 0px; font-style: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><wbr style="margin: 0px; padding: 0px;"></wbr></span><span class="ob_org_header" style="border: 0px; float: left; font-style: inherit; font-weight: 600; margin: 0px; outline: 0px; padding: 0px 0px 3px; text-align: left; vertical-align: baseline;"></span></div> </div> </div> </div> <span style="background-color: rgba(255, 255, 255, 0);">- See more at: http://www.vanguardngr.com/2014/08/nine-questions-new-ebola-drug/#sthash.2eWIM9Po.dpuf</span></div>

Nine questions about new Ebola drug

Two American missionary workers infected with the deadly Ebola virus were given an experimental drug that seems to have saved their lives....

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