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<span style="background-color: rgba(255, 255, 255, 0);">'Promising' Ebola vaccine to go into trials - and it could be available by the end of the year</span><br />
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<li class="" style="list-style: none; margin: 0px; padding: 0px;"><strong style="background-color: rgba(255, 255, 255, 0);">60 healthy volunteers will be given the vaccine next month in Oxford trial</strong></li>
<li class="" style="list-style: none; margin: 0px; padding: 0px;"><strong style="background-color: rgba(255, 255, 255, 0);">If vaccine performs as well in humans as in monkeys, trial will be extended</strong></li>
<li class="" style="list-style: none; margin: 0px; padding: 0px;"><strong style="background-color: rgba(255, 255, 255, 0);">Entire trial programme is being fast-tracked – subject to ethical approval</strong></li>
<li class="" style="list-style: none; margin: 0px; padding: 0px;"><strong style="background-color: rgba(255, 255, 255, 0);">Hoped vaccine can be used in high-risk people in West Africa early next year</strong></li>
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<span style="background-color: rgba(255, 255, 255, 0);"><img alt="60 healthy volunteers will be given the vaccine next month in a trial led by Oxford University scientists" class="blkBorder img-share" data-track-pos="0" height="546" id="i-87bd365536dd2dbf" src="http://i.dailymail.co.uk/i/pix/2014/08/28/1409242759162_Image_galleryImage_This_undated_handout_phot.JPG" style="border: 1px solid rgb(0, 0, 0); margin: 0px; padding: 0px;" width="306" /></span><div class="overlay-icon mobile-gallery" style="background-position: 0% 50%; background-repeat: no-repeat no-repeat; border-bottom-left-radius: 3px; border-bottom-right-radius: 3px; border-top-left-radius: 3px; border-top-right-radius: 3px; bottom: 11px; box-sizing: border-box; display: table; height: 36px; margin: 0px; min-height: 1px; padding: 0px; position: absolute; right: 10px;">
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<span style="background-color: rgba(255, 255, 255, 0);">60 healthy volunteers will be given the vaccine next month in a trial led by Oxford University scientists</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Britons are to be the first in the world to test a new vaccine against the deadly ebola virus.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Altogether 60 healthy volunteers will be given the vaccine next month in a trial led by Oxford University scientists.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">If the vaccine performs as well in humans as in monkeys, the trial will be extended to 80 people in The Gambia and in Mali.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The entire trial programme is being fast-tracked – subject to ethical approval – with the intention of using the vaccine in people at high risk in West Africa early next year.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Latest figures show that more than 1,550 people have died from the virus, with more than 3,000 confirmed cases - mostly in Guinea, Liberia and Sierra Leone.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">It is the worst epidemic since the disease was first identified 38 years ago and the World Health Organization (WHO) predicts the outbreak will last for many months, affecting at least 20,000 people.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">At present there is no vaccine to prevent the disease and no proven treatment.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The new vaccine contains a single ebola virus protein from the strain sweeping West Africa – anyone inoculated with it cannot develop the disease itself.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">It is different from the experimental medicine ZMapp being used to treat William Pooley, the first Briton to contract the virus while working as a nurse at a remote health centre in Sierra Leone.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The 29-year-old is currently in isolation at London’s Royal Free Hospital.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The new trial will be led by Professor Adrian Hill, of the Jenner Institute at Oxford University, which has unprecedented experience in carrying out trials using similar types of vaccine.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">He said the speed with which arrangements had been made was unparalleled in 20 years of experience in the field.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">He said: ‘The tragic events unfolding in Africa demand an urgent response.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">‘In recent years, similar investigational vaccines have safely immunised infants and adults against a range of diseases including malaria, HIV and Hepatitis C.</span></div>
<span style="background-color: rgba(255, 255, 255, 0);"><br /><br />Read more: <a href="http://www.dailymail.co.uk/health/article-2736932/Ebola-vaccine-discovered-British-scientists-available-end-year.html#ixzz3Bi5bBu4R" style="cursor: pointer; margin: 0px; min-height: 1px; padding: 0px; text-decoration: none;">http://www.dailymail.co.uk/health/article-2736932/Ebola-vaccine-discovered-British-scientists-available-end-year.html#ixzz3Bi5bBu4R</a><br />Follow us: <a href="http://ec.tynt.com/b/rw?id=bBOTTqvd0r3Pooab7jrHcU&u=MailOnline" style="cursor: pointer; margin: 0px; min-height: 1px; padding: 0px; text-decoration: none;" target="_blank">@MailOnline on Twitter</a> | <a href="http://ec.tynt.com/b/rf?id=bBOTTqvd0r3Pooab7jrHcU&u=DailyMail" style="cursor: pointer; margin: 0px; min-height: 1px; padding: 0px; text-decoration: none;" target="_blank">DailyMail on Facebook</a></span><br />
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<span style="background-color: rgba(255, 255, 255, 0);">‘We, and all our partners on this project, are optimistic that this candidate vaccine may prove useful against ebola.’</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The vaccine is being co-developed by the US National Institutes of Health (NIH) and pharmaceutical giant GlaxoSmithKline, along with a dual vaccine containing proteins against both West Africa and Sudan strains of ebola which is being trialled in the US.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The UK initiative is backed by a £2.8 million grant from the Wellcome Trust, the Medical Research Council and the UK Department for International Development.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The consortium’s funding will also enable GSK to begin manufacturing up to around 10,000 additional doses of the vaccine at the same time as the initial clinical trials.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);"><img alt="The new vaccine is different from the experimental medicine ZMapp being used to treat William Pooley, the first Briton to contract the virus while working as a nurse at a remote health centre in Sierra Leone" class="blkBorder img-share" data-track-pos="1" height="765" id="i-2b1bd03f07530486" src="http://i.dailymail.co.uk/i/pix/2014/08/28/1409242795857_Image_galleryImage_Copyright_Albanpix_com_Wi.JPG" style="border: 1px solid rgb(0, 0, 0); margin: 0px; padding: 0px;" width="634" /></span><div class="overlay-icon mobile-gallery" style="background-position: 0% 50%; background-repeat: no-repeat no-repeat; border-bottom-left-radius: 3px; border-bottom-right-radius: 3px; border-top-left-radius: 3px; border-top-right-radius: 3px; bottom: 11px; box-sizing: border-box; display: table; height: 36px; margin: 0px; min-height: 1px; padding: 0px; position: absolute; right: 10px;">
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<span style="background-color: rgba(255, 255, 255, 0);">The new vaccine is different from the experimental medicine ZMapp being used to treat William Pooley, the first Briton to contract the virus while working as a nurse at a remote health centre in Sierra Leone</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">If the trials are successful stocks could then be made available immediately by GSK to the WHO to create an emergency immunisation programme for high-risk communities.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Each set of volunteers will be split into groups of 20 that will receive different doses of the vaccine so researchers can evaluate the best dose to use in terms of both safety and activity.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0); font-weight: bold;"><span style="font-size: small;">EBOLA COULD AFFECT MORE THAN 20,000, HEALTH CHIEFS WARN </span></span></h3>
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<span style="background-color: rgba(255, 255, 255, 0);">The current Ebola outbreak in West Africa could infect more than 20,000 people, the World Health Organisation has revealed in a bleak assessment of the deadly disease.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The United Nations health agency issued plans to combat the outbreak in four West African nations - Guinea, Sierra Leone, Liberia and Nigeria - where it said the actual number of cases could already be two to four times higher than the reported 3,069.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The current death toll stands at 1,552.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Describing plans to tackle the West African outbreak, the WHO said: 'This roadmap assumes that in many areas of intense transmission the actual number of cases may be two-four fold higher than that currently reported.'</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The deadly West African outbreak that began in Guinea in March and has since spread to Liberia, Sierra Leone and Nigeria, requires a massive and coordinated international response, the WHO said. </span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">It is being tested here and in West Africa to take account of differences between the different populations that might affect safety or immune response.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Prof Hill said successful completion of both stages of the trial in healthy volunteers could mean the vaccine is ready for large-scale use early in 2015.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">He said results from studies in monkeys suggest a good safety profile from the single ebola virus protein, which produced high levels of antibodies and immune-boosting white blood cells.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">As it does not contain infectious virus material, it cannot cause a person who is vaccinated to become infected with ebola.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">The duration of response could only be discovered in ‘real-life’ situations but even if it only lasted a few months it would be enough to contain outbreaks, he said.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Dr Jeremy Farrar, director of the Wellcome Trust, said: ‘This epidemic has shown how difficult it can be to control ebola.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">‘How useful drugs and vaccines might be in complementing existing public health interventions can only be assessed in epidemics.</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">‘The initial safety work we’re announcing today with our international partners will hopefully make that possible during this crisis and for inevitable future epidemics.’</span></div>
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<span style="background-color: rgba(255, 255, 255, 0);">Chief Medical Officer, Dame Sally Davies said she was pleased GSK had chosen the UK to apply for the first phase of human testing for the vaccine. </span></div>
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'Promising' Ebola vaccine to go into trials - and it could be available by the end of the year

'Promising' Ebola vaccine to go into trials - and it could be available by the end of the year 60 healthy volunteers will be give...

'Promising' Ebola vaccine to go into trials - and it could be available by the end of the year

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